DUGRAM (Gemifloxacin mesilate) 320mg Tablets

DRUG CATEGORY: Broad Spectrum Quinolone

MECHANISM OF ACTION: DUGRAM works by inhibiting the topoisomerase IV and topoisomerase II (DNA gyrase) enzymes that are involved in the DNA replication. This inhibition weakens DNA strands, leading to DNA damage and bacterial cell death. In Gram-negative organisms DNA gyrase is the primary target, whereas in Gram-positive bacteria Topoisomerase IV was recently found to be most affected. DUGRAM is a dual targeting fluoroquinolone. Therefore, DUGRAM has the lowest mutant rate of both Topoisomerase IV and DNA gyrase, causing the lowest resistant rate among the comparators.

INDICATIONS: Acute bacterial sinusitis. ,Acute bacterial exacerbation of chronic bronchitis, Community acquired pneumonia. , Un-complicated Urinary tract infection., Acute pyelonephiritis

DOSAGE AND ADMINISTRATION: 320mg once daily with recommended regimens of 3 to 7 days depending on the indication and individual patient’s condition.

PRESENTATION: DUGRAM (Gemifloxacin) 320mg tablets are available in alu-alu blister pack of 1x 7’s