LEFODIL (Leflunomide) 20mg Tablets

DRUG CATEGORY: Anti-Rheumatic (DMARD’s)

MECHANISM OF ACTION: Leflunomide is an isoxazole immunomodulatory agent which inhibits dihydroorotate dehydrogenase (an enzyme involved in de novo pyrimidine synthesis) and has antiproliferative activity. Leflunomide blocks the de novo synthesis of pyrimidines, thus preventing the proliferation of activated T cells. Several in vivo and in vitro experimental models have demonstrated an anti-inflammatory effect.

INDICATIONS: Lefodil is indicated in adults for the treatment of active moderate to severe rheumatoid arthritis and psoriatic arthritis (Inflammatory Arthritis with psoriasis)

DOSAGE AND ADMINISTRATION: Loading Dose Due to the long half-life in patients with RA and recommended dosing interval (24 hours), a loading dose is needed to provide steady-state concentrations more rapidly. It is recommended that Lefodil therapy be initiated with a loading dose of one 100 mg tablet per day for 3 days. (A loading dose is sometimes given for medicines that take a long time to build up in the body) Maintenance Therapy Daily dosing of 20 mg is recommended for treatment of patients with RA. If dosing at 20 mg/day is not well tolerated clinically, the dose may be decreased to 10 mg daily.

PRESENTATION: Lefodil 20mg Tablets are present in Alu-Alu Blister pack of 3×10’s Tablets