NEOFLOX (Pefloxacin) 400mg Tablets

DRUG CATEGORY: Fluoroquinolone antibiotic

MECHANISM OF ACTION: The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

INDICATIONS: Urinary tract infections, Respiratory tract infections, typhoid fever, E.N.T infections in neutropenic patients, anthrax, billiary tract infections, infected bites & stings, bone & joint infections, cat scratch disease, gonorrhea. fever, septicemia, skin infections, spotted fever, meningococcal meningitis. surgical infections prophylaxis. Treatment of opportunistic mycobacterial infections, tuberculosis, Gastroenteritis including traveller’s diarrhoea. Campylobacter enteritis, cholera. Salmonella enteritis and Shigellosis.

DOSAGE AND ADMINISTRATION: Adults and children over 15 years, an oral dose of 400mg every twelve hours, during meals to avoid G.I.T disturbances.

PRESENTATION: Neoflox 400mg Tabs. are available in blister pack of 2×5’s Tabs.