DUMAL -S Tablets (Artemether 80mg + Lumefantrine 480mg)

DRUG CATEGORY: Anti-Malarial

MECHANISM OF ACTION The exact mechanisms of action of artemether and lumefantrine are unknown, but both agents appear to act on the parasite’s organelles. Artemether’s action depends on its endoperoxide bridge, which interacts with heme iron to cause free radical damage to the malaria parasite. Lumefantrine most likely interferes with heme polymerization, which is a critical detoxifying pathway for the malaria parasite.  Both agents may have secondary actions that include inhibition of parasite nucleic acid and protein synthesis.

INDICATIONS: Treatment of uncomplicated P. falciparum malaria including multi-drug resistant strains of P. falciparum. Also effective against the blood stage of P. vivax.

DOSAGE AND ADMINISTRATION:1 tablet at the time of initial diagnosis then 1 tablet at 8, 24 & 48 hrs there after (total of 4 tabs. in all)

PRESENTATION:Dumal-S 80/480mg Tabs., blister pack of 1×4’s tablets